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Mr David Schoepfer

Mr David Schoepfer

Research Associate

Sainsbury Laboratory
University of Cambridge
47 Bateman Street

Cambridge CB2 1LR
Office Phone: +44(0)1223 761100

Research Interests

Plants are highly sensitive to ambient temperature, with small changes in temperature capable of triggering substantial modifications in plant growth and development. In the model plant Arabidopsis thaliana, hundreds of genes undergo transcriptional reprogramming within minutes of exposure to heat, a process regulated in part by heat-shock factors. The Wigge laboratory has demonstrated that transcriptional regulation of temperature responses involves changes in occupancy of the histone variant H2A.Z, though the means by which this chromatin alteration occurs is unknown. Despite considerable efforts to identify temperature sensors in plants, the primary mechanism of temperature perception remains to be discovered. In parallel to an on-going forward genetic screen being conducted by the Wigge laboratory, I am using a chemical genomics approach to identify proteins required for temperature signaling in A. thaliana. As well as identifying key components of temperature signaling pathways in plants, this project could potentially identify chemicals with useful agricultural applications, such as thermal protection of plant reproduction.

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