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Meyerowitz Group

Elliot Meyerowitz

Distinguished Associate

Laboratory's Inaugural Director (Jan 2011-Dec 2012)

Sainsbury Laboratory Cambridge
University of Cambridge
Bateman Street

Cambridge CB2 1LR

Office Phone: 01223 761107

Research Interests

My laboratory has the goal of understanding the mechanisms of plant development, using both experimental and computational methods to test hypotheses. We concentrate on the shoot apical meristem and its derivative structures (primarily flowers), because this meristem is responsible for the development of the entire above-ground part of the mature plant, and utilizes a number of different pattern-forming processes that are as yet poorly understood. Our experimental organism is predominantly Arabidopsis thaliana, because of the ease with which genetic and molecular biological studies can be done using that model system. We also use other plant species in the laboratory when they offer an experimental advantage. Our method of study is what we have termed Computational Morphodynamics – the combination of real-time live imaging to capture the dynamics of plant development, couching our hypotheses as mathematical models (so as to be absolutely explicit about assumptions and parameters), and then testing them computationally and experimentally. We concentrate on three processes in plant development - the development of flowers, the growth of shoots, and the de novo generation of shoot meristems during regeneration.

Key Publications

Roeder, A.H.K., Cunha, A., Burl, M.C. and Meyerowitz, E.M. (2012) Computational image analysis glossary for biologists. Development, in press.

Chickarmane, V.S., Gordon, S.P., Tarr, P.T., Heisler, M.G. and Meyerowitz, E.M. (2012) Cytokinin signaling as a positional cue for patterning the apical-basal axis of the growing Arabidopsis shoot meristem. Proc. Natl. Acad. Sci USA, 109, 4002-4007 DOI: 10.1073/pnas.1200636109

Cunha, A., Tarr, P.T., Roeder, A.H.K., Altinok, A., Mjolsness, E. and Meyerowitz, E.M. (2012) Computational analysis of live cell images of the Arabidopsis thaliana plant. Methods Cell Biol. 110, 285-323.

Wagner D. and Meyerowitz E.M. (2011) Switching on flowers: transient LEAFY induction reveals novel aspects of the regulation of reproductive development in Arabidopsis. Front. Plant Sci. 2:60, 1-6. DOI: 10.3389/fpls.2011.00060

Romanel, E., Das, P., Amasino, R.M., Traas, J., Meyerowitz, E.M. and Alves-Ferreira, M. (2011) Reproductive Meristem22 is a unique marker for the early stages of stamen development. Int. J. Dev. Biol. 55, 657-664. DOI: 10.1387/ijdb.113340er

Roeder, A.H.K., Tarr, P.T., Tobin, C., Zhang, X., Chickarmane, V., Cunha, A. and Meyerowitz, E.M. (2011) Computational morphodynamics of plants: integrating development over space and time. Nature Reviews Molec. Cell Biology 12, 265-273. PMCID: PMC2867943 DOI: 10.1038/nrm3079

Sugimoto, K., Gordon, S.P. and Meyerowitz, E.M. (2011) Regeneration in plants and animals: dedifferentiation, transdifferentiation, or just differentiation? Trends Cell Biol. 21, 212-218. DOI: 10.1016/j.tcb.2010.12.004

Nimchuk, Z.L., Tarr, P.T. and Meyerowitz, E.M. (2011) An evolutionarily conserved pseudo-kinase mediates stem cell production in plants. Plant Cell 21, 345-352. PMCID: PMC3082267 DOI: 10.1105/tpc.110.075622

Nimchuk, Z.L., Tarr, Paul T., Ohno, C., Qu, X. and Meyerowitz, E.M. (2011) Signaling in the Arabidopsis shoot meristem stem cell niche correlates with ligand-dependent trafficking of the CLV1 receptor kinase. Current Biology 21, 345-352. PMCID: PMC3072602 DOI: 10.1016/j.cub.2011.01.039

Jaillais, Y., Hothorn, M., Belkhadir, Y., Dabi, T., Nimchuk, Z.L., Meyerowitz, E.M. and Chory, J. (2011) Tyrosine phosphorylation controls brassinosteroid receptor activation by triggering membrane release of its kinase inhibitor. Genes Devel. 25, 232-237.

Jiao, Y. and Meyerowitz, E.M. (2010) Cell-type specific analysis of translating RNAs in developing flowers reveals new levels of control. Molec. Systems Biol. 6: 419. doi:10.1038/msb.2010.76

Heisler, M.G., Hamant, O., Krupinski, P., Uyttewaal, M., Ohno, C., Jönsson, H., Traas, J. and Meyerowitz, E.M. (2010) Alignment between PIN1 polarity and microtubule orientation in the shoot apical meristem reveals a tight coupling between morphogenesis and auxin transport. PLoS Biology 8, e1000516. doi:10.1371/journal.pbio.1000516

Roeder, A.H.K., Chickarmane, V., Cunha, A., Obara, B., Manjunath B.S. and Meyerowitz E.M. (2010) Variability in the control of cell division underlies sepal epidermal patterning in Arabidopsis thaliana. PLoS Biology 8, e1000367. doi:10.1371/journal.pbio.1000367.

Kaufmann, K., Wellmer, F., Muiño, J.M., Ferrier, T., Wuest, S.E., Kumar, V., Serrano-Mislata, A., Madueño, F., Krajewski, P., Meyerowitz, E.M., Angenent, G.C. and Riechmann, J.L. (2010) Orchestration of floral initiation by APETALA1. Science 328, 85-89.

Sugimoto, K., Jiao, Y. and Meyerowitz, E.M. (2010) Arabidopsis regeneration from multiple tissues occurs via a root development pathway. Developmental Cell 18, 463-471.

Gordon, S.P., Chickarmane, V.S., Ohno, C. and Meyerowitz, E.M. (2009) Multiple feedback loops through cytokinin signaling control stem cell number within the Arabidopsis shoot apical meristem. Proc. Natl. Acad. Sci. USA 106, 16529-16534.

Das, P., Ito, T., Wellmer, F., Vernoux, T., Dedieu, A., Traas, J. and Meyerowitz, E.M. (2009) Floral stem cell termination involves the direct regulation of AGAMOUS by PERIANTHIA. Development 136, 1605-1611.

Harrison, C.J., Roeder, A.H.K., Meyerowitz, E.M. and Langdale, J.A. (2009) Local cues and asymmetric cell divisions underpin body plan transitions in the moss Physcomitrella patens. Curr. Biol. 19, 461-471.

Hamant, O., Heisler, M., Jönsson, H., Krupinski, P., Uyttewaal, M., Bokov, P., Corson, F., Sahlin, P., Boudaoud, A., Meyerowitz, E.M., Couder, Y. and Traas, J. (2008) Developmental patterning by mechanical signals in Arabidopsis. Science 322, 1650-1655.

Jiao, Y., Riechmann, J.L. and Meyerowitz, E.M. (2008) Transcriptome-wide analysis of uncapped mRNAs in Arabidopsis. Plant Cell 20, 2571-2585.

Li, D., Liu, C., Shen, L., Wu, Y., Chen, H., Robertson, M., Helliwell, C.A., Ito, T., Meyerowitz, E., and Yu, H. (2008) A Repressor Complex Governs the Integration of Flowering Signals in Arabidopsis. Developmental Cell 15, 110-120.

Haswell, E.S., Peyronnet, R., Barbier-Brygoo, H., Meyerowitz, E.M. and Frachisse, J.M. (2008) Two MscS homologs provide mechanosensitive channel activities in the Arabidopsis root. Curr. Biol. 18, 730-734.