skip to primary navigationskip to content
 

Schornack Group

Sebastian Schornack   

Web of Science Highly Cited Researchers logo

Research Group Leader

Sainsbury Laboratory Cambridge
University of Cambridge
Bateman Street

Cambridge CB2 1LR

Office Phone: 01223 761145

Research Interests

Plants constantly engage in interactions with microbial organisms. These interactions can either be detrimental such as those with the economically relevant fungus-like oomycete Phytophthora infestans, the causal agent of the Irish Potato Famine or beneficial to supply phosphate such as in symbiotic interactions with mycorrhizal fungi that occur in most plant species.

Both, pathogenic and mutualistic symbioses follow structurally similar developmental processes to establish intracellular interfaces. It is generally accepted that both, plants and microorganisms contribute to the formation of dedicated accommodation structures. However, we know little about the underlying molecular mechanisms that drive differentiation of host cells and tissues to form intracellular interfaces.

The Schornack group aims to characterize the extent to which beneficial and detrimental microorganisms employ similar plant developmental processes for colonization. To this end we plan to assess the overlap between Mycorrhiza processes and root infection by the biotrophic pathogen Phytophthora palmivora and will characterize genetic elements with common functions. Furthermore, we will elucidate the role of microbial effectors for development of plant cells into intracellular accommodation structures. This work will reveal the boundaries between symbiosis and pathogenesis and will provide novel insights into plant development driven by biotic cues. 

Selected Recent Publications

Carella, P., Gogleva, A., Tomaselli, M., Alfs, C., and Schornack, S. (2018) Phytophthora palmivora establishes tissue-specific intracellular infection structures in the earliest divergent land plant lineage. PNAS (Online Early: https://doi.org/10.1073/pnas.1717900115) Previously on bioRxiv (2017, Pre-Print). doi: https://doi.org/10.1101/188912. Watch the video about this research.

Evangelisti E., Gogleva A., Hainaux H., Doumane M., Tulin F., Quan C., Yunusov T., Floch K., Schornack S. (2017) Time-resolved dual transcriptomics reveal early induced Nicotiana benthamiana root genes and conserved infection-promoting Phytophthora palmivora effectors. BMC Biol. https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-017-0379-1

Rey T., Chatterjee A.,Buttay M., Toulotte J., Schornack S. (2014) Medicago truncatula symbiosis mutants affected in the interaction with a biotrophic root pathogen. New Phytol. http://onlinelibrary.wiley.com/doi/10.1111/nph.13233/full

Wang E., Schornack S., Marsh J.F., Gobbato E., Schwessinger B., Eastmond P., Schultze M., Kamoun S., Oldroyd G.E. (2012) A Common Signaling Process that Promotes Mycorrhizal and Oomycete Colonization of Plants. Curr Biol. 22(23)

Bozkurt, T.O.*, Schornack, S.*, Win, J., Shindo, T., Oliva, R., Cano, L.M., Jones, A.M.E., Huitema, E., van der Hoorn, R.A.L., Kamoun, S. (2011) Phytophthora infestans effector AVRblb2 prevents focal secretion of a plant immune protease, Proc Natl Acad Sci USA 108(51), * shared first authors

Chaparro-Garcia A., Wilkinson R.C., Gimenez-Ibanez S., Findlay K., Coffey M.D., Zipfel C., Rathjen J.P., Kamoun S.*, Schornack S.* (2011) The Receptor-Like Kinase SERK3/BAK1 Is Required for Basal Resistance against the Late Blight Pathogen Phytophthora infestans in Nicotiana benthamiana. PLoS ONE 6(1). * shared corresponding authors

Schornack S.*, van Damme M.*, Bozkurt T.O., Cano L.M., Smoker M., Thines M., Gaulin E., Kamoun S., Huitema E. (2010): Ancient class of translocated oomycete effectors targets the host nucleus. Proc Natl Acad Sci USA 107(40). * shared corresponding authors

Selected reviews

Carella, P., and Schornack, S. (2017) Manipulation of bryophyte hosts by pathogenic and symbiotic microbes. Plant and Cell Physiology, pcx182, https://doi.org/10.1093/pcp/pcx182

Fawke, S., Doumane, M., Schornack, S. (2015): Oomycete Interactions with Plants: Infection Strategies and Resistance Principles, Microbiol Mol Biol Rev.

http://mmbr.asm.org/content/79/3/263.abstract

Rey T., Schornack S. (2013): Interactions of beneficial and detrimental root-colonizing filamentous microbes with plant hosts. Genome Biol. 14(6). Review.

Schornack S., Moscou M.J., Ward E.R., Horvath D.M. (2013): Engineering Plant Disease Resistance Based on TAL Effectors. Annu Rev Phytopathol. 51. Review.

Schornack S., Huitema E., Cano L.M., Bozkurt T.O., Oliva R., Van Damme M., Schwizer S., Raffaele S., Chaparro-Garcia A., Farrer R., Segretin M.E., Bos J., Haas B.J., Zody M.C., Nusbaum C., Win J., Thines M., Kamoun S. (2009): Ten things to know about oomycete effectors. Mol Plant Pathol. 10(6). Review.

Group members

schornack2.jpgRed fluorescent Phytophthora colonising a Medicago truncatula (barrel medic) root

schornack1.jpg

A GFP-labelled protein functions at Phytophthora haustoria structures

 
Former Group Members:

Thomas Rey

Abhishek Chatterjee

Margaux Buttay

Ruth Le Fevre

Felicity George

Winston Tan

Silvian Baltac

Samuel Kroll

Laura Bouvet

Mehdi Doumane

Justine Toulotte

Ayoub Kadoussi

Elsa Weissbrich

Emma J Lawrence

Bridget O'Boyle

Carolin Alfs Aug

Thomas Hainaux

Catherine Page

Anthony Bridgen

Lara Busby

Haruka Kobayashi

Marta Tomaselli

Guillaume Chesneau

Angel Vergara Cruces

Philipp Rink

Alice McDowell

Yuchen Xie

Annika Luebbe

Marie Le Naour-Vernet

 

Research supported by:

royal society logoGatsbyuc-colour.gif

Read more here.