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Dr Benoit Landrein

Dr Benoit Landrein

Post Doctoral Researcher

Sainsbury Laboratory
University of Cambridge
Bateman Street

Cambridge CB2 1LR
Office Phone: +44(0)1223 761100

Research Interests

My scientific interest is in the study of the complex process of morphogenesis, which comprises all the chemical and physical mechanisms at stake during development for multicellular organisms to acquire definite and robust shapes. My model system is the shoot apical meristem of Arabidopsis as this structure located at the tip of every stem is responsible for the emergence of all the aerial organs of the plant. I have a background in Molecular Biology but aim in using multidisciplinary approaches by combining experiments and modelling to answer complex questions of development. During my PhD, performed with Olivier Hamant in the Laboratory of Plant Development and Reproduction (Lyon, France), I was interested in the relationship between patterning and growth. I studied how mechanical forces resulting from shape changes in the meristem could influence gene expression. I have also looked at the influence of meristematic and post-meristematic growth on the spatial arrangement of the organs on Arabidopsis stems (phyllotaxis). In this post-doctorate where I joined the teams of Henrik Jönsson, James Locke and Elliot Meyerowitz at SLCU, I am looking more precisely at the mechanisms of patterning by studying the dynamics of gene regulatory networks in the meristem using both experimental approaches and computational modelling.

Key Publications

Landrein B, Kiss A, Sassi M, Chauvet A, Das P, Cortizo M, Laufs P, Takeda S, Aida M, Traas J, Vernoux T, Boudaoud A, Hamant O. (2015) Mechanical stress contributes to the expression of the STM homeobox gene in Arabidopsis shoot meristems. eLife

Landrein B, Refahi Y, Besnard F, Hervieux N, Mirabet V, Boudaoud A, Vernoux T, Hamant O. (2015) Meristem size contributes to the robustness of phyllotaxis in Arabidopsis. J Exp Bot. 66(5)

Landrein B, Lathe R, Bringmann M, Vouillot C, Ivakov A, Boudaoud A, Persson S, Hamant O. (2013) Impaired cellulose synthase guidance leads to stem torsion and twists phyllotactic patterns in Arabidopsis. Current Biology 23(10)

Uyttewaal M, Burian A, Alim K, Landrein B, Borowska-Wykręt D, Dedieu A, Peaucelle A, Ludynia M, Traas J, Boudaoud A, Kwiatkowska D, Hamant O. (2012) Mechanical stress acts via katanin to amplify differences in growth rate between adjacent cells in Arabidopsis. Cell 149(2)

Reviews

Landrein B, Hamant O. (2013) How mechanical stress controls microtubule behaviour and morphogenesis in plants: history, experiments and revisited theories. Plant Journal 75(2)

Landrein B and Vernoux T. (2014) Auxin, chief architect of the shoot Apex (2014), Springer Book: Auxin and its role in plant development