Henrik Jönsson
Director of SLCU
University of Cambridge
Bateman Street
Cambridge CB2 1LR
Office Phone: 01223 761128
Research Interests
The focus of our research is to develop Computational Morphodynamics models at the cellular level describing multicellular tissues such as the shoot apical meristem. The models are developed in close collaboration with experimental groups and describe the dynamics of gene regulatory networks, hormone transport and signalling, cell growth and division, and mechanical properties. Integral for the research is the iterative evaluation of the models and their parameters to new experimental data, mainly in the form of live microscopy data.
One focus is on the understanding of the development of new primordia at the periphery of the shoot apex, where the phytohormone auxin is focused to the sites where new organs form, and this is accomplished via an intricate feedback to its own transport. At the same time physical stresses can provide the required intercellular connection for the regulated transport. We also suggest that stresses are sensed when creating new fibers, such that primordia growth becomes regulated and correlated with the positioning. The models we develop hence require a mechanistic description of molecular reactions transport and signalling, physical stresses and growth, and the possibility of interactions in between.
Another problem we are studying is the regulation and plasticity of the cells in the shoot apical meristem, which keeps its general cell differentiation pattern throughout the life of a plant, even if the cells are replaced during the symplastic growth where cells are moving out of the meristem tissue. We have focused on developing models for gene regulation and intercellular signalling, where the experimentally known CLAVATA-WUSCHEL negative feedback provides the core of the network. We develop models and optimise and evaluate model parameters towards large sets of perturbation experiments, where our approach focus on regions of parameters to describe the model network behavior. Also of interest is the receptor cross-talk that is part of this regulatory system.
Publications
Visit Henrik's Google Scholar profile to view all his publications
Xyloglucan deficiency leads to a reduction in turgor pressure and changes in cell wall properties, affecting early seedling establishment
FB Daher, L Serra, R Carter, H Jönsson, S Robinson, EM Meyerowitz, WM Gray
Current Biology 34 (10), 2094-2106. e6, 2024
Available at: https://www.cell.com/current-biology/fulltext/S0960-9822(24)00456-1
Raw data for Xyloglucan deficiency leads to a reduction in turgor pressure and changes in cell wall properties affecting early seedling establishment
F Bou Daher, L Serra, R Carter, H Jönsson, S Robinson, EM Meyerowitz, WM Gray
Available at: https://conservancy.umn.edu/bitstream/handle/11299/262082/BouDaher_2024_...
Hibiscus bullseyes reveal mechanisms controlling petal pattern proportions that influence plant-pollinator interactions
L Riglet, A Zardilis, AL Fairnie, MTS Yeo, H Jonsson, E Moyroud
bioRxiv, 2024.02. 05.579006, 2024
Available at: https://www.science.org/doi/full/10.1126/sciadv.adp5574
Mean-field theory approach to three-dimensional nematic phase transitions in microtubules
C Gibson, H Jönsson, TA Spelman
Physical Review E 108 (6), 064414, 2023
Available at: https://link.aps.org/pdf/10.1103/PhysRevE.108.064414
Stiffness transitions in new walls post-cell division differ between Marchantia polymorpha gemmae and Arabidopsis thaliana leaves.
A Bonfanti, ET Smithers, M Bourdon, A Guyon, P Carella, R Carter, R Wightman, S Schornack, H Jönsson…
Proceedings of the National Academy of Sciences of the United States of …, 2023
Available at: https://www.pnas.org/doi/full/10.1073/pnas.2302985120
Differential Growth is an Emergent Property of Mechanochemical Feedback Mechanisms in Curved Plant Organs
A Walia, R Carter, R Wightman, EM Meyerowitz, H Jönsson, AM Jones
Available at SSRN 4677553, 2023
Available at: https://papers.ssrn.com/sol3/Delivery.cfm?abstractid=4677553
Sugar signaling modulates SHOOT MERISTEMLESS expression and meristem function in Arabidopsis
FL Lopes, P Formosa-Jordan, A Malivert, L Margalha, A Confraria, R Feil, JE Lunn, H Jönsson, B Landrein…
bioRxiv, 2023.01. 08.522175, 2023
Available at: https://www.pnas.org/doi/pdf/10.1073/pnas.2408699121
Context-specific functions of transcription factors controlling plant development: from leaves to flowers
MG Heisler, H Jönsson, S Wenkel, K Kaufmann
Current Opinion in Plant Biology 69, 102262, 2022
Available at: https://www.sciencedirect.com/science/article/pii/S1369526622000917
A 3D gene expression atlas of the floral meristem based on spatial reconstruction of single nucleus RNA sequencing data
M Neumann, X Xu, C Smaczniak, J Schumacher, W Yan, N Blüthgen, T Greb, H Jönsson, J Traas, K Kaufmann…
Nature Communications 13 (1), 2838, 2022
Available at: https://www.nature.com/articles/s41467-022-30177-y.pdf
High-throughput 3D phenotyping of plant shoot apical meristems from tissue-resolution data
HP Åhl, Y Zhang, H Jönsson
Frontiers in plant science, 712, 2022
Available at: https://www.frontiersin.org/articles/10.3389/fpls.2022.827147/full
KATANIN and CLASP function at different spatial scales to mediate microtubule response to mechanical stress in Arabidopsis cotyledons
RC Eng, R Schneider, TW Matz, R Carter, DW Ehrhardt, H Jönsson, Z Nikoloski, A Sampathkumar
Current Biology 31 (15), 3262-3274. e6, 2021
Available at: https://www.cell.com/current-biology/fulltext/S0960-9822(21)00678-3
Molecular mechanism of cytokinin-activated cell division in Arabidopsis
W Yang, S Cortijo, N Korsbo, P Roszak, K Schiessl, A Gurzadyan, R Wightman, H Jönsson, E Meyerowitz
Science 371 (6536), 1350-1355, 2021
Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166333/
Tissue folding at the organ–meristem boundary results in nuclear compression and chromatin compaction
K Fal, N Korsbo, J Alonso-Serra, J Teles, M Liu, Y Refahi, ME Chabouté, H Jönsson, O Hamant
Proceedings of the National Academy of Sciences 118 (8), 2021
Available at: https://www.pnas.org/doi/pdf/10.1073/pnas.2017859118
A multiscale analysis of early flower development in Arabidopsis provides an integrated view of molecular regulation and growth control
…, A Armezzani, AE Risson, F Zhao, P Das, N Prunet, EM Meyerowitz, C Godin, G Malandain, H Jönsson…
Developmental Cell 56 (4), 540-556. e8, 2021
Available at: https://www.cell.com/developmental-cell/pdf/S1534-5807(21)00077-0.pdf
Limits and Constraints on Mechanisms of Cell-Cycle Regulation Imposed by Cell Size-Homeostasis Measurements
L Willis, H Jönsson, KC Huang
Cell Reports 32 (6), 107992, 2020
Available at: https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30977-3
Cytoskeletal organization in isolated plant cells under geometry control
P Durand-Smet, TA Spelman, EM Meyerowitz, H Jönsson
Proceedings of the National Academy of Sciences 117 (29), 17399-17408, 2020
Available at: https://www.pnas.org/doi/pdf/10.1073/pnas.2003184117
Auxin transport model for leaf venation
J Haskovec, H Jönsson, LM Kreusser, P Markowich
Proceedings of the Royal Society A 475 (2231), 20190015, 2019
Available at: https://royalsocietypublishing.org/doi/pdf/10.1098/rspa.2019.0015?downlo...
Mechanical asymmetry of the cell wall predicts changes in pavement cell geometry
M Majda, P Krupinski, H Jönsson, O Hamant, S Robert
Developmental cell 50 (1), 9-10, 2019
Available at: https://www.cell.com/developmental-cell/pdf/S1534-5807(19)30487-3.pdf
Anisotropic growth is achieved through the additive mechanical effect of material anisotropy and elastic asymmetry
FB Daher, Y Chen, B Bozorg, J Clough, H Jönsson, SA Braybrook
Elife 7, e38161, 2018
Available at: https://elifesciences.org/articles/38161.pdf
The self-organization of plant microtubules inside the cell volume yields their cortical localization, stable alignment, and sensitivity to external cues
V Mirabet, P Krupinski, O Hamant, EM Meyerowitz, H Jönsson, A Boudaoud
PLoS computational biology 14 (2), e1006011, 2018
Available at: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1...
Nitrate modulates stem cell dynamics in Arabidopsis shoot meristems through cytokinins
…, A Malivert, C Schuster, CW Melnyk, W Yang, C Turnbull, EM Meyerowitz, JCW Locke, H Jönsson
Proceedings of the National Academy of Sciences 115 (6), 1382-1387, 2018
Available at: https://www.pnas.org/doi/full/10.1073/pnas.1718670115
Mechanochemical Polarization of Contiguous Cell Walls Shapes Plant Pavement Cells
M Majda, P Grones, IM Sintorn, T Vain, P Milani, P Krupinski, B Zagórska-Marek, C Viotti, H Jönsson…
Developmental cell 43 (3), 290-304. e4, 2017
Available at: https://www.cell.com/developmental-cell/pdf/S1534-5807(17)30830-4.pdf
Cell type boundaries organize plant development
MP Caggiano, X Yu, N Bhatia, A Larsson, H Ram, CK Ohno, P Sappl, EM Meyerowitz, H Jönsson, MG Heisler
Elife 6, e27421, 2017
Available at: https://elifesciences.org/articles/27421
Different reprogramming propensities in plants and mammals: Are small variations in the core network wirings responsible?
V Olariu, J Nilsson, H Jönsson, C Peterson
PloS one 12 (4), e0175251, 2017
Available at: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0175251
Fluctuations of the transcription factor ATML1 generate the pattern of giant cells in the Arabidopsis sepal
HM Meyer, J Teles, P Formosa-Jordan, Y Refahi, R San-Bento, G Ingram, H Jönsson, JCW Locke, AHK Roeder
eLife 6, e19131, 2017
Available at: https://elifesciences.org/articles/19131
Cell size and growth regulation in the Arabidopsis thaliana apical stem cell niche
L Willis, Y Refahi, R Wightman, B Landrein, J Teles, KC Huang, EM Meyerowitz, H Jönsson
Proceedings of the National Academy of Sciences 113 (51), E8238-E8246, 2016
Available at: https://www.pnas.org/doi/pdf/10.1073/pnas.1616768113
Auxin acts through MONOPTEROS to regulate plant cell polarity and pattern phyllotaxis
N Bhatia, B Bozorg, A Larsson, C Ohno, H Jönsson, MG Heisler
Current Biology 26 (23), 3202-3208, 2016
Available at: https://www.cell.com/current-biology/fulltext/S0960-9822(16)31128-9?cc=y%3D&_returnURL=http://linkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0960982216311289%3Fsh...
A continuous growth model for plant tissue
B Bozorg, P Krupinski, H Jönsson
Physical Biology 13 (6), 065002, 2016
Available at: https://www.repository.cam.ac.uk/bitstreams/0c55cd45-1052-4475-ae7e-33e5...
A model analysis of mechanisms for radial microtubular patterns at root hair initiation sites
P Krupinski, B Bozorg, A Larsson, S Pietra, M Grebe, H Jönsson
Frontiers in plant science 7, 1560, 2016
Available at: https://www.frontiersin.org/articles/10.3389/fpls.2016.01560/pdf
Signaling from maize organ primordia via FASCIATED EAR3 regulates stem cell proliferation and yield traits
…, ED Arevalo, AL Eveland, Q Wu, A Goldshmidt, R Meeley, M Bartlett, M Komatsu, H Sakai, H Jönsson…
Nature genetics 48 (7), 785-791, 2016
Available at: https://www.repository.cam.ac.uk/bitstreams/43fbc753-8b5f-4f84-a869-030b...
Spatio-temporal registration of 3D microscopy image sequences of Arabidopsis floral meristems
G Michelin, Y Refahi, R Wightman, H Jönsson, J Traas, C Godin, G Malandain
Biomedical Imaging (ISBI), 2016 IEEE 13th International Symposium on, 1127-1130, 2016
Available at: https://inria.hal.science/hal-01251151/document
Shifting foundations: the mechanical cell wall and development
S Braybrook, H Jönsson
Current Opinion in Plant Biology 29, 115-120, 2016
Available at: https://www.sciencedirect.com/science/article/pii/S136952661530011X
An epidermis-driven mechanism positions and scales stem cell niches in plants
J Gruel, B Landrein, P Tarr, C Schuster, Y Refahi, A Sampathkumar, O Hamant, EM Meyerowitz, H Jönsson
Science Advances 2, e1500989, 2016
Available at: https://www.science.org/doi/pdf/10.1126/sciadv.1500989
Subcellular and supracellular mechanical stress prescribes cytoskeleton behavior in Arabidopsis cotyledon pavement cells
A Sampathkumar, P Krupinski, R Wightman, P Milani, A Berquand, A Boudaoud, O Hamant, H Jönsson…
Elife 3, e01967, 2014
Available at: https://elifesciences.org/articles/1967
Stress and strain provide positional and directional cues in development
B Bozorg, P Krupinski, H Jönsson
PLoS computational biology 10 (1), e1003410, 2014
Available at: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1...
The moss Physcomitrella patens reproductive organ development is highly organized, affected by the two SHI/STY genes and by the level of active auxin in the SHI/STY expression domain
K Landberg, ERA Pederson, T Viaene, B Bozorg, J Friml, H Jönsson, M Thelander, E Sundberg
Plant physiology 162, 1406-1419, 2013
Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707547/
Plant stem cell maintenance involves direct transcriptional repression of differentiation program
RK Yadav, M Perales, J Gruel, C Ohno, M Heisler, T Girke, H Jönsson, GV Reddy
Molecular Systems Biology 9 (1), 2013
Available at: https://www.embopress.org/doi/pdf/10.1038/msb.2013.8
On evaluating models in computational morphodynamics
H Jönsson, J Gruel, P Krupinski, C Troein
Current opinion in plant biology 15 (1), 103-110, 2012
Available at: http://home.thep.lu.se/~henrik/mnxa09/Jonsson2012.pdf
Models of sequestration and receptor cross-talk for explaining multiple mutants in plant stem cell regulation
P Sahlin, P Melke, H Jönsson
BMC systems biology 5 (1), 2, 2011
Available at: https://link.springer.com/content/pdf/10.1186/1752-0509-5-2.pdf
Alignment between PIN1 polarity and microtubule orientation in the shoot apical meristem reveals a tight coupling between morphogenesis and auxin transport
MG Heisler, O Hamant, P Krupinski, M Uyttewaal, C Ohno, H Jönsson, J Traas, EM Meyerowitz
PLoS biology 8 (10), e1000516, 2010
Available at: https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.10...
A modeling study on how cell division affects properties of epithelial tissues under isotropic growth
P Sahlin, H Jönsson
PloS one 5 (7), e11750, 2010
Available at: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0011750
A cell-based model for quorum sensing in heterogeneous bacterial colonies
P Melke, P Sahlin, A Levchenko, H Jönsson
PLoS computational biology 6 (6), e1000819, 2010
Available at: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1...
Modeling plant growth and pattern formation
H Jönsson, P Krupinski
Current opinion in plant biology 13 (1), 5-11, 2010
Available at: https://www.academia.edu/download/44340225/1.pdf
Modeling auxin-regulated development
P Krupinski, H Jönsson
Cold Spring Harbor perspectives in biology 2 (2), a001560, 2010
Available at: https://cshperspectives.cshlp.org/content/2/2/a001560.full.htmlref-list-1
