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Sainsbury Laboratory

Read more at: Dr Eva Hellmann

Dr Eva Hellmann

Research interests


Read more at: Professor Henrik Jönsson

Professor Henrik Jönsson

Professor Henrik Jönsson is Director of the Sainsbury Laboratory and Professor of Computational Morphodynamics.

Journal articles

2023

  • Bonfanti, A., Smithers, ET., Bourdon, M., Guyon, A., Carella, P., Carter, R., Wightman, R., Schornack, S., Jönsson, H. and Robinson, S., 2023. Stiffness transitions in new walls post-cell division differ between Marchantia polymorpha gemmae and Arabidopsis thaliana leaves. Proc Natl Acad Sci U S A, v. 120
    Doi: http://doi.org/10.1073/pnas.2302985120
  • Gibson, C., Jönsson, H. and Spelman, TA., 2023. Mean-field theory approach to three-dimensional nematic phase transitions in microtubules. Phys Rev E, v. 108
    Doi: 10.1103/PhysRevE.108.064414
  • 2022

  • Neumann, M., Xu, X., Smaczniak, C., Schumacher, J., Yan, W., Blüthgen, N., Greb, T., Jönsson, H., Traas, J., Kaufmann, K. and Muino, JM., 2022. A 3D gene expression atlas of the floral meristem based on spatial reconstruction of single nucleus RNA sequencing data. Nat Commun, v. 13
    Doi: http://doi.org/10.1038/s41467-022-30177-y
  • Heisler, MG., Jönsson, H., Wenkel, S. and Kaufmann, K., 2022. Context-specific functions of transcription factors controlling plant development: From leaves to flowers. Curr Opin Plant Biol, v. 69
    Doi: http://doi.org/10.1016/j.pbi.2022.102262
  • Åhl, H., Zhang, Y. and Jönsson, H., 2022. High-Throughput 3D Phenotyping of Plant Shoot Apical Meristems From Tissue-Resolution Data. Front Plant Sci, v. 13
    Doi: http://doi.org/10.3389/fpls.2022.827147
  • 2021 (Accepted for publication)

  • Jonsson, S., Fal, K., Korsbo, N., Teles, J., Refahi, Y., Hamant, O., Alonso-Serra, J., Liu, M. and Chaboute, ME., 2021 (Accepted for publication). Tissue folding at the organ-meristem boundary results in nuclear compression and chromatin compaction Proceedings of the National Academy of Sciences of USA,
  • Zardilis, A., Refahi, Y. and Jonsson, S., 2021 (Accepted for publication). A multiscale analysis of early flower development in Arabidopsis provides an integrated view of molecular regulation and growth control. Developmental Cell,
  • 2021

  • Eng, RC., Schneider, R., Matz, TW., Carter, R., Ehrhardt, DW., Jönsson, H., Nikoloski, Z. and Sampathkumar, A., 2021. KATANIN and CLASP function at different spatial scales to mediate microtubule response to mechanical stress in Arabidopsis cotyledons. Curr Biol, v. 31
    Doi: http://doi.org/10.1016/j.cub.2021.05.019
  • Wightman, R., Yang, W., Cortijo, S., Korsbo, N., Jonsson, S., Roszak, P., Schiessl, K., Gurzadyan, A. and Meyerowitz, E., 2021. Molecular mechanism of cytokinin-activated cell division in Arabidopsis Science,
    Doi: http://doi.org/10.1126/science.abe2305
  • 2020 (Accepted for publication)

  • Willis, L., Jonsson, S. and Huang, KC., 2020 (Accepted for publication). Limits and constraints on mechanisms of cell-cycle regulation imposed by cell size-homeostasis measurements Cell Reports,
  • Durand-Smet, P., Spelman, TA., Meyerowitz, EM. and Jönsson, H., 2020 (Accepted for publication). Cytoskeletal organization in isolated plant cells under geometry control Proceedings of the National Academy of Sciences of USA,
    Doi: http://doi.org/10.1073/pnas.2003184117
  • 2020

  • Korsbo, N. and Jönsson, H., 2020. It's about time: Analysing simplifying assumptions for modelling multi-step pathways in systems biology. PLoS Comput Biol, v. 16
    Doi: http://doi.org/10.1371/journal.pcbi.1007982
  • 2019

  • Bhatia, N., Åhl, H., Jönsson, H. and Heisler, MG., 2019. Quantitative analysis of auxin sensing in leaf primordia argues against proposed role in regulating leaf dorsoventrality. Elife, v. 8
    Doi: http://doi.org/10.7554/eLife.39298
  • Bhatia, N., Ahl, H., Jonsson, H. and Heisler, MG., 2019. Quantitative analysis of auxin sensing in leaf primordia argues against proposed role in regulating leaf dorsoventrality ELIFE, v. 8
    Doi: http://doi.org/10.7554/eLife.39298
  • Korsbo, N. and Jönsson, H., 2019. It’s about time: Analysing an alternative approach for reductionist modelling of linear pathways in systems biology
    Doi: http://doi.org/10.1101/781708
  • Haskovec, J., Jönsson, H., Kreusser, LM. and Markowich, P., 2019. Auxin transport model for leaf venation Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, v. 475
    Doi: http://doi.org/10.1098/rspa.2019.0015
  • Jönsson, H., 2019. The rise of a forgotten model. Nat Rev Mol Cell Biol, v. 20
    Doi: http://doi.org/10.1038/s41580-019-0144-0
  • Majda, M., Krupinski, P., Jönsson, H., Hamant, O. and Robert, S., 2019. Mechanical Asymmetry of the Cell Wall Predicts Changes in Pavement Cell Geometry. Dev Cell, v. 50
    Doi: http://doi.org/10.1016/j.devcel.2019.06.002
  • 2018 (Accepted for publication)

  • Jonsson, SH., Mirabet, V., Krupinski, P., Hamant, O., Meyerowitz, EM. and Boudaoud, A., 2018 (Accepted for publication). The self-organization of plant microtubules inside the cell volume yields their cortical localization, stable alignment, and sensitivity to external cues PLoS Computational Biology,
  • Gruel, JAP., Deichmann, J., Landrein, B., Hitchcock, T. and Jönsson, H., 2018 (Accepted for publication). The interaction of transcription factors controls the spatial layout of plant aerial stem cell niches npj Systems Biology and Applications,
    Doi: http://doi.org/10.1038/s41540-018-0072-1
  • 2018

  • Jonsson, H., Meyerowitz, , Landrein, BPM., Formosa-Jordan, , Malivert, , Schuster, C., Melnyk, CW., Yang, W., Turnbull, and Locke, JCW., 2018. Nitrate modulates stem cell dynamics in Arabidopsis shoot meristems through cytokinins Proceedings of the National Academy of Sciences of the United States of America, v. 115
    Doi: http://doi.org/10.1073/pnas.1718670115
  • Bou Daher, F., Chen, Y., Bozorg, B., Clough, J., Jönsson, H. and Braybrook, SA., 2018. Anisotropic growth is achieved through the additive mechanical effect of material anisotropy and elastic asymmetry. Elife, v. 7
    Doi: http://doi.org/10.7554/eLife.38161
  • 2017 (Accepted for publication)

  • Meyer, HM., Teles, J., Formosa-Jordan, P., Refahi, Y., San-Bento, R., Ingram, G., Jönsson, H., Locke, JCW. and Roeder, AHK., 2017 (Accepted for publication). Fluctuations of the transcription factor ATML1 generate the pattern of giant cells in the $\textit{Arabidopsis}$ sepal eLife, v. 6
    Doi: http://doi.org/10.7554/eLife.19131
  • Jönsson, H., 2017 (Accepted for publication). Mechano-chemical polarization of contiguous cell walls shapes plant pavement cells Developmental Cell,
  • 2017

  • Meyer, HM., Teles, J., Formosa-Jordan, P., Refahi, Y., San-Bento, R., Ingram, G., Jonsson, H., Locke, JCW. and Roeder, AHK., 2017. Fluctuations of the transcription factor ATML1 generate the pattern of giant cells in the Arabidopsis sepal eLife, v. 6
    Doi: http://doi.org/10.7554/elife.19131
  • Olariu, V., Nilsson, J., Jönsson, H. and Peterson, C., 2017. Different reprogramming propensities in plants and mammals: Are small variations in the core network wirings responsible? PLoS One, v. 12
    Doi: http://doi.org/10.1371/journal.pone.0175251
  • Caggiano, MP., Yu, X., Bhatia, N., Larsson, A., Ram, H., Ohno, CK., Sappl, P., Meyerowitz, EM., Jönsson, H. and Heisler, MG., 2017. Cell type boundaries organize plant development Elife, v. 2017
    Doi: http://doi.org/10.7554/eLife.27421
  • Mirabet, V., Krupinski, P., Hamant, O., Meyerowitz, EM., Jönsson, H. and Boudaoud, A., 2017. The self-organization of plant microtubules in three dimensions enable stable cortical localization and sensitivity to external cues
    Doi: 10.1101/210138
  • Landrein, B., Formosa-Jordan, P., Malivert, A., Schuster, C., Melnyk, C., Yang, W., Turnbull, C., Meyerowitz, E., Locke, JCW. and Jönsson, H., 2017. Nitrate modulates stem cell dynamics by regulating<i>WUSCHEL</i>expression through cytokinins
    Doi: http://doi.org/10.1101/200303
  • 2016

  • Willis, L., Refahi, Y., Wightman, R., Landrein, B., Teles, J., Huang, KC., Meyerowitz, EM. and Jönsson, H., 2016. Cell size and growth regulation in the $\textit{Arabidopsis thaliana}$ apical stem cell niche Proceedings of the National Academy of Sciences (PNAS), v. 113
    Doi: http://doi.org/10.1073/pnas.1616768113
  • Braybrook, SA. and Jönsson, H., 2016. Shifting foundations: the mechanical cell wall and development. Curr Opin Plant Biol, v. 29
    Doi: http://doi.org/10.1016/j.pbi.2015.12.009
  • Gruel, J., Landrein, B., Tarr, P., Schuster, C., Refahi, Y., Sampathkumar, A., Hamant, O., Meyerowitz, EM. and Jönsson, H., 2016. An epidermis-driven mechanism positions and scales stem cell niches in plants. Sci Adv, v. 2
    Doi: http://doi.org/10.1126/sciadv.1500989
  • Je, BI., Gruel, J., Lee, YK., Bommert, P., Arevalo, ED., Eveland, AL., Wu, Q., Goldshmidt, A., Meeley, R., Bartlett, M., Komatsu, M., Sakai, H., Jönsson, H. and Jackson, D., 2016. Signaling from maize organ primordia via FASCIATED EAR3 regulates stem cell proliferation and yield traits. Nat Genet, v. 48
    Doi: http://doi.org/10.1038/ng.3567
  • Bhatia, N., Bozorg, B., Larsson, A., Ohno, C., Jönsson, H. and Heisler, MG., 2016. Auxin Acts through MONOPTEROS to Regulate Plant Cell Polarity and Pattern Phyllotaxis. Curr Biol, v. 26
    Doi: http://doi.org/10.1016/j.cub.2016.09.044
  • Krupinski, P., Bozorg, B., Larsson, A., Pietra, S., Grebe, M. and Jönsson, H., 2016. A Model Analysis of Mechanisms for Radial Microtubular Patterns at Root Hair Initiation Sites Frontiers in Plant Science, v. 7
    Doi: http://doi.org/10.3389/fpls.2016.01560
  • Bozorg, B., Krupinski, P. and Jönsson, H., 2016. A continuous growth model for plant tissue Physical Biology, v. 13
    Doi: http://doi.org/10.1088/1478-3975/13/6/065002
  • 2014

  • Sampathkumar, A., Krupinski, P., Wightman, R., Milani, P., Berquand, A., Boudaoud, A., Hamant, O., Jönsson, H. and Meyerowitz, EM., 2014. Subcellular and supracellular mechanical stress prescribes cytoskeleton behavior in Arabidopsis cotyledon pavement cells. Elife, v. 3
    Doi: http://doi.org/10.7554/eLife.01967
  • 2013

  • Yadav, RK., Perales, M., Gruel, J., Ohno, C., Heisler, M., Girke, T., Jönsson, H. and Venugopala Reddy, G., 2013. Plant stem cell maintenance involves direct transcriptional repression of differentiation program Molecular Systems Biology, v. 9
    Doi: http://doi.org/10.1038/msb.2013.8
  • Landberg, K., Pederson, ERA., Viaene, T., Bozorg, B., Friml, J., Jönsson, H., Thelander, M. and Sundberg, E., 2013. The moss physcomitrella patens reproductive organ development is highly organized, affected by the two SHI/STY genes and by the level of active auxin in the SHI/STY expression domain Plant Physiology, v. 162
    Doi: http://doi.org/10.1104/pp.113.214023
  • 2012

  • Jönsson, H., Gruel, J., Krupinski, P. and Troein, C., 2012. On evaluating models in Computational Morphodynamics Current Opinion in Plant Biology, v. 15
    Doi: http://doi.org/10.1016/j.pbi.2011.09.007
  • 2011

  • John, M., 2011. A is for Abstract. HSR Proc Intensive Care Cardiovasc Anesth, v. 3
  • Yadav, RK., Perales, M., Gruel, J., Girke, T., Jönsson, H. and Reddy, GV., 2011. WUSCHEL protein movement mediates stem cell homeostasis in the Arabidopsis shoot apex Genes Dev, v. 25
    Doi: http://doi.org/10.1101/gad.17258511
  • Jönsson, H., Gruel, J., Krupinski, P. and Troein, C., 2011. On evaluating models in Computational Morphodynamics Curr Opin Plant Biol,
    Doi: http://doi.org/10.1016/j.pbi.2011.09.007
  • Sahlin, P., Melke, P. and Jonsson, H., 2011. Models of sequestration and receptor cross-talk for explaining multiple mutants in plant stem cell regulation BMC systems biology, v. 5
    Doi: http://doi.org/10.1186/1752-0509-5-2
  • 2010

  • Melke, P., Sahlin, P., Levchenko, A. and Jönsson, H., 2010. A cell-based model for quorum sensing in heterogeneous bacterial colonies PLoS Comput Biol, v. 6
    Doi: http://doi.org/10.1371/journal.pcbi.1000819
  • Sahlin, P. and Jönsson, H., 2010. A modeling study on how cell division affects properties of epithelial tissues under isotropic growth PLoS ONE, v. 5
    Doi: http://doi.org/10.1371/journal.pone.0011750
  • Krupinski, P. and Jönsson, H., 2010. Modeling Auxin-regulated Development Cold Spring Harb Perspect Biol, v. 2
    Doi: http://doi.org/10.1101/cshperspect.a001560
  • Jönsson, H., Heisler, MG., Hamant, O., Krupinski, P., Uyttewaal, M., Ohno, C., Traas, J. and Meyerowitz, EM., 2010. Alignment between PIN1 polarity and microtubule orientation in the shoot apical meristem reveals a tight coupling between morphogenesis and auxin transport PLoS Biology, v. 8
    Doi: http://doi.org/10.1371/journal.pbio.1000516
  • Melke, P., Sahlin, P., Levchenko, A. and Jönsson, H., 2010. A cell-based model for quorum sensing in heterogeneous bacterial colonies PLoS Computational Biology, v. 6
    Doi: http://doi.org/10.1371/journal.pcbi.1000819
  • Jönsson, H. and Krupinski, P., 2010. Modeling plant growth and pattern formation Curr Opin Plant Biol, v. 13
    Doi: http://doi.org/10.1016/j.pbi.2009.10.002
  • Heisler, MG., Hamant, O., Krupinski, P., Uyttewaal, M., Ohno, C., Jönsson, H., Traas, J. and Meyerowitz, EM., 2010. Alignment between PIN1 polarity and microtubule orientation in the shoot apical meristem reveals a tight coupling between morphogenesis and auxin transport PLoS Biol, v. 8
    Doi: http://doi.org/10.1371/journal.pbio.1000516
  • 2009

  • Sahlin, P., Hamant, O. and Jönsson, H., 2009. Statistical Properties of Cell Topology and Geometry in a Tissue-Growth Model Complex Sciences,
    Doi: http://doi.org/10.1007/978-3-642-02466-5_97
  • Sahlin, P., Söderberg, B. and Jönsson, H., 2009. Regulated transport as a mechanism for pattern generation: capabilities for phyllotaxis and beyond J Theor Biol, v. 258
    Doi: http://doi.org/10.1016/j.jtbi.2009.01.019
  • 2008

  • Hamant, O., Heisler, MG., Jönsson, H., Krupinski, P., Uyttewaal, M., Bokov, P., Corson, F., Sahlin, P., Boudaoud, A., Meyerowitz, EM., Couder, Y. and Traas, J., 2008. Developmental patterning by mechanical signals in Arabidopsis Science, v. 322
    Doi: http://doi.org/10.1126/science.1165594
  • 2007

  • Heisler, MG. and Jönsson, H., 2007. Modelling meristem development in plants Curr Opin Plant Biol, v. 10
    Doi: http://doi.org/10.1016/j.pbi.2006.11.005
  • Cho, H., Jönsson, H., Campbell, K., Melke, P., Williams, JW., Jedynak, B., Stevens, AM., Groisman, A. and Levchenko, A., 2007. Self-organization in high-density bacterial colonies: efficient crowd control PLoS Biol, v. 5
    Doi: http://doi.org/10.1371/journal.pbio.0050302
  • Cho, HJ., Jönsson, H., Campbell, K., Melke, P., Williams, JW., Jedynak, B., Stevens, AM., Groisman, A. and Levchenko, A., 2007. Self-organization in high-density bacterial colonies: Efficient crowd control PLoS Biology, v. 5
    Doi: http://doi.org/10.1371/journal.pbio.0050302
  • 2006

  • Jönsson, H., Heisler, MG., Shapiro, BE., Meyerowitz, EM. and Mjolsness, E., 2006. An auxin-driven polarized transport model for phyllotaxis Proc Natl Acad Sci USA, v. 103
    Doi: http://doi.org/10.1073/pnas.0509839103
  • Melke, P., Jönsson, H., Pardali, E., Dijke, PT. and Peterson, C., 2006. A rate equation approach to elucidate the kinetics and robustness of the TGF-beta pathway Biophys J, v. 91
    Doi: http://doi.org/10.1529/biophysj.105.080408
  • Heisler, M. and Jönsson, H., 2006. Modeling auxin transport and plant development J Plant Growth Regul,
  • Heisler, MG. and Jönsson, H., 2006. Modeling auxin transport and plant development Journal of Plant Growth Regulation, v. 25
    Doi: http://doi.org/10.1007/s00344-006-0066-x
  • Heisler, MG. and Jönsson, H., 2006. Computer modeling of plant development Journal of Plant Growth Regulation, v. 25
    Doi: http://doi.org/10.1007/s00344-006-0080-z
  • 2005

  • Jönsson, H., Heisler, M., Reddy, GV., Agrawal, V., Gor, V., Shapiro, BE., Mjolsness, E. and Meyerowitz, EM., 2005. Modeling the organization of the WUSCHEL expression domain in the shoot apical meristem Bioinformatics, v. 21 Suppl 1
    Doi: http://doi.org/10.1093/bioinformatics/bti1036
  • Jonsson, H. and Levchenko, A., 2005. An explicit spatial model of yeast microcolony growth Multiscale Modeling and Simulation,
  • Jönsson, H. and Levchenko, A., 2005. An explicit spatial model of yeast microcolony growth Multiscale Modeling and Simulation, v. 3
    Doi: http://doi.org/10.1137/040603255
  • 2003

  • Jönsson, H. and Söderberg, B., 2003. An approximate maximum likelihood approach, applied to phylogenetic trees. J Comput Biol, v. 10
    Doi: http://doi.org/10.1089/106652703322539060
  • Jönsson, H., Shapiro, B. and Meyerowitz, E., 2003. Signaling in multicellular models of plant development On Growth,
  • 2002

  • Jönsson, H. and Söderberg, B., 2002. An information-based neural approach to generic constraint satisfaction Artificial Intelligence, v. 142
    Doi: http://doi.org/10.1016/S0004-3702(02)00291-6
  • 2001

  • Jönsson, H. and Söderberg, B., 2001. An information-based neural approach to constraint satisfaction. Neural Comput, v. 13
    Doi: http://doi.org/10.1162/08997660152469369
  • Datasets

    2022 (No publication date)

  • Åhl, H., Zhang, Y. and Jönsson, H., 2022 (No publication date). Research data supporting "High-throughput 3D phenotyping of plant shoot apical meristems from tissue-resolution data"
  • 2020 (No publication date)

  • Durand, P., Spelman, T., Jönsson, H. and Meyerowitz, E., 2020 (No publication date). Research data supporting "Cytoskeletal organisation in isolated plant cells under geometry control"
  • Fal, K., Korsbo, N., Alonso-Serra, J., Teles, J., Liu, M., Chabouté, M-E., Jonsson, S. and Hamant, O., 2020 (No publication date). Research data supporting Tissue folding at the organ-meristem boundary results in nuclear compression and chromatin compaction
  • Refahi, Y., Traas, J., Jönsson, H. and Zardilis, A., 2020 (No publication date). Research data supporting "A multiscale analysis of early flower development in Arabidopsis provides an integrated view of molecular regulation and growth control"
  • 2019 (No publication date)

  • Kreusser, L., Haskovec, J., Jönsson, H. and Markowich, P., 2019 (No publication date). Research data supporting 'Auxin transport model for leaf venation'
  • 2018 (No publication date)

  • Gruel, J., Deichmann, J., Landrein, B., Hitchcock, T. and Jonsson, H., 2018 (No publication date). Research data supporting "The spatial layout of plant aerial stem cell niches is controlled by the interaction of transcription factors".
  • Landrein, BPM., Formosa-Jordan, P., Malivert, A., Schuster, C., Melnyk, CW., Yang, W., Turnbull, C., Meyerowitz, EM., Locke, JCW. and Jönsson, H., 2018 (No publication date). Research data supporting "Nitrate modulates stem cell dynamics in Arabidopsis shoot meristems through cytokinins"
  • 2017 (No publication date)

  • Jonsson, SH., Willis, L. and Refahi, Y., 2017 (No publication date). Research data supporting Cell size and growth regulation in the Arabidopsis thaliana apical stem cell niche
  • Book chapters

    2018 (Accepted for publication)

  • Jonsson, SH., Formosa-Jordan, P. and Teles, J., 2018 (Accepted for publication). Single-cell approaches for understanding morphogenesis using Computational Morphodynamics
    Doi: http://doi.org/10.1007/978-3-319-99070-5_6
  • 2003

  • Jönsson, H., Shapiro, BE., Meyerowitz, EM. and Mjolsness, E., 2003. 8 Signalling in multicellular models of plant development
    Doi: http://doi.org/10.1016/b978-012428765-5/50041-4
  • Conference proceedings

    2017

  • Bhatia, N., Bozorg, B., Ohno, C., Jonsson, H. and Heisler, M., 2017. The regulation of cell polarity and organ positioning in plants MECHANISMS OF DEVELOPMENT, v. 145
    Doi: http://doi.org/10.1016/j.mod.2017.04.182
  • 2016

  • Michelin, G., Refahi, Y., Wightman, R., Jonsson, H., Traas, J., Godin, C. and Malandain, G., 2016. Spatio-temporal registration of 3D microscopy image sequences of arabidopsis floral meristems Proceedings - International Symposium on Biomedical Imaging, v. 2016-June
    Doi: http://doi.org/10.1109/ISBI.2016.7493464