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Dr Jérémy Gruel

Dr Jérémy Gruel

Post Doctoral Researcher

Sainsbury Laboratory
University of Cambridge
Bateman Street

Cambridge CB2 1LR
Office Phone: +44(0)1223 761100

Research Interests

Life displays complexity in many different layers; complex ecosystems emerge from simple organisms, complex organisms emerge from simple cells, complex cells emerge from simple molecules.

Often, our complex brains produce too simple a mind to grasp at the collective behavior of the parts making one of these layers. Computational modeling can make up for our shortcomings, allowing us to implement elementary rules to piece together pieces of the bigger puzzle. Led by this grand purpose, or maybe unfit for pipetting and lab coats, I joined the IT crowd of biology.

Over the past few years, I have been working on TGF-beta receptor trafficking in the context of liver fibrosis and regulation of gene expression by transcription factors. More recently, I have focused on gene expression patterning in the shoot apical meristem of plants, especially focusing on the CLAVATA-WUSCHEL feedback loop.

Key Publications

Signaling from maize organ primordia via FASCIATED EAR3 regulates stem cell proliferation and yield traits. Je, BI, Gruel, J*, Lee, YK*, Bommert, P, Arevalo, ED, Eveland, AL, Wu, Q, Goldshmidt, A, Meeley, R, Bartlett, M, Komatsu, M, Sakai, H, Jönsson, H, Jackson, D. Nat. Genet. (2016), 48, 7:785-91.

An epidermis-driven mechanism positions and scales stem cell niches in plants. Gruel, J, Landrein, B*, Tarr, P*, Schuster, C, Refahi, Y, Sampathkumar, A, Hamant, O, Meyerowitz, EM, Jönsson, H.  Sci Adv (2016), 2, 1:e1500989.

Plant stem cell maintenance involves direct transcriptional repression of differentiation program.Yadav RK*, Perales M*, Gruel J*, Ohno C, Heisler M, Girke T, Jönsson H, Reddy GV. Mol Syst Biol. 2013;9:654.

On evaluating models in Computational Morphodynamics. Jönsson H, Gruel J, Krupinski P, Troein C. Curr Opin Plant Biol. 2012 Feb;15(1):103-10. Epub 2011 Oct 13.

WUSCHEL protein movement mediates stem cell homeostasis in the Arabidopsis shoot apex. Yadav RK, Perales M, Gruel J, Girke T, Jönsson H, Reddy GV.Genes Dev. 2011 Oct 1;25(19):2025-30.

Simple Shared Motifs (SSM) in conserved region of promoters: a new approach to identify co-regulation patterns. Gruel J, LeBorgne M, LeMeur N, Théret N. BMC Bioinformatics. 2011 Sep 12;12:365.

In silico investigation of ADAM12 effect on TGF-beta receptors trafficking. Gruel J, Leborgne M, LeMeur N, Théret N. BMC Res Notes. 2009 Sep 24;2:193.

Curating a Large-Scale Regulatory Network by Evaluating Its Consistency with Expression Datasets Guziolowski C, Gruel J, Radulescu O, Siegel A. Computational Intelligence Methods for Bioinformatics and Biostatistics Lecture Notes in Computer Science, 2009

Filed under:

gruelresearch

Exploration of the parameter space of a model. In red are parameter sets producing the desired behaviour: describing three gene expression domains of interest of the SAM. An example is shown below. From left to right, the Organizing Center, the Central Zone and the Peripheral Zone.

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